Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism

Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism

Abstract Background The release of extracellular vesicles (EVs) including exosomes from human mesenchymal stroma/stem-like cells (MSC) represents valuable cell-free carriers for the delivery of regenerative and medicinal compounds. Methods EVs/exosomes were isolated by differential centrifugation fr...

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Bibliographic Details
Main Authors: Ralf Hass, Juliane von der Ohe, Tianjiao Luo
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Cell Communication and Signaling
Subjects:
Mesenchymal stroma cells
Chemotherapeutics
Extracellular vesicles
Exosomes
Tumor plasticity
Tumor tropism
Online Access:https://doi.org/10.1186/s12964-024-01886-2
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https://doi.org/10.1186/s12964-024-01886-2

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