IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis

IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis

Non-alcoholic fatty liver disease (NAFLD) is a hepatic metabolic syndrome arising from lipid metabolic imbalance, with its prevalence increasing globally. In this study, we observed a significant up-regulation of interferon regulatory factor 8 (IRF8) in the liver of NAFLD model mice and patients. Ov...

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Bibliographic Details
Main Authors: Xinyue Li, Hong Zhang, Fan Yu, Shuting Xie, Tongyu Wang, Rong Zhang, Guangzhong Xu, Liang Wang, Yeping Huang, Cheng Hu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-05-01
Series:Genes and Diseases
Subjects:
Brain and muscle ARNT-Like 1
Hepatic steatosis
Interferon regulatory factor 8
Lipogenesis
Non-alcoholic fatty liver disease
Peroxisome proliferator-activated receptor γ
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224001302
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