Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

Abstract Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which might be a potential target for the e...

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Main Authors: Peng-yu Duan, Yuan Ma, Xi-na Li, Feng-zhi Qu, Liang Ji, Xiao-yu Guo, Wang-jun Zhang, Fan Xiao, Le Li, Ji-sheng Hu, Bei Sun, Gang Wang
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-019-0278-3
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https://doi.org/10.1038/s12276-019-0278-3

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