A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis

A peptide mimic of SOCS1 modulates equine peripheral immune cells in vitro and ocular effector functions in vivo: implications for recurrent uveitis

IntroductionRecurrent uveitis (RU), an autoimmune disease, is a leading cause of ocular detriment in humans and horses. Equine and human RU share many similarities including spontaneous disease and aberrant cytokine signaling. Reduced levels of SOCS1, a critical regulator of cytokine signaling, is a...

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Bibliographic Details
Main Authors: Lauren Stewart Stafford, Caryn E. Plummer, W. Clay Smith, Daniel J. Gibson, Jatin Sharma, Valeria Vicuna, Sisse Diakite, Joseph Larkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
suppressor of cytokine signaling 1 (SOCS1)
recurrent uveitis
equine (horse)
spontaneous model
ocular immunity
PBMC (peripheral blood mononucleated cells)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1513157/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1513157/full

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