Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study
Cushing’s syndrome (CS) may alter the performance of the hypothalamic-hypophyseal-thyroid axis. We searched for a relationship between hypercortisolism and primary thyroid disorders. The medical records of 40 patients with CS were retrospectively examined. Thyroid ultrasonography (USG), basal thyroi...
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/732736 |
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| author | Eda Demir Onal Muhammed Sacikara Fatma Saglam Reyhan Ersoy Bekir Cakir |
| author_facet | Eda Demir Onal Muhammed Sacikara Fatma Saglam Reyhan Ersoy Bekir Cakir |
| author_sort | Eda Demir Onal |
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| description | Cushing’s syndrome (CS) may alter the performance of the hypothalamic-hypophyseal-thyroid axis. We searched for a relationship between hypercortisolism and primary thyroid disorders. The medical records of 40 patients with CS were retrospectively examined. Thyroid ultrasonography (USG), basal thyroid function test results (TFT), and antithyroglobulin and antithyroperoxidase antibodies were analyzed. In 80 control subjects, matched by age and gender with CS patients, thyroid USG, TFTs, and autoantibody panel were obtained. Among the CS patients, 17 had nodular goiter, versus 24 controls (42.5% versus 30%, P>0.05). Among the twenty-five patients with an available TFT and autoantibody panel—before and after surgical curative treatment—autoantibody positivity was detected in 2 (8%) patients before and 3 (12%) after surgery (P=0.48). Regarding TFT results, 1 (2.5%) patient had subclinical hyperthyroidism and 1 (2.5%) had subclinical hypothyroidism, whereas 1 (2.5%) control had hyperthyroidism. In total, 21 (52.5%) patients and 32 (40%) controls had ≥1 of the features of thyroid disorder, including goiter, positive thyroid autoantibody, and thyroid function abnormality; the difference was not significant (P>0.05). The prevalence of primary thyroid disorders is not significantly increased in patients with CS. |
| format | Article |
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| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-df6211feed0b4af293f0c7e62905f17d2025-02-03T01:25:52ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/732736732736Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational StudyEda Demir Onal0Muhammed Sacikara1Fatma Saglam2Reyhan Ersoy3Bekir Cakir4Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10/6, Ceyhun Atıf Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10/6, Ceyhun Atıf Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10/6, Ceyhun Atıf Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10/6, Ceyhun Atıf Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, TurkeyDepartment of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10/6, Ceyhun Atıf Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, TurkeyCushing’s syndrome (CS) may alter the performance of the hypothalamic-hypophyseal-thyroid axis. We searched for a relationship between hypercortisolism and primary thyroid disorders. The medical records of 40 patients with CS were retrospectively examined. Thyroid ultrasonography (USG), basal thyroid function test results (TFT), and antithyroglobulin and antithyroperoxidase antibodies were analyzed. In 80 control subjects, matched by age and gender with CS patients, thyroid USG, TFTs, and autoantibody panel were obtained. Among the CS patients, 17 had nodular goiter, versus 24 controls (42.5% versus 30%, P>0.05). Among the twenty-five patients with an available TFT and autoantibody panel—before and after surgical curative treatment—autoantibody positivity was detected in 2 (8%) patients before and 3 (12%) after surgery (P=0.48). Regarding TFT results, 1 (2.5%) patient had subclinical hyperthyroidism and 1 (2.5%) had subclinical hypothyroidism, whereas 1 (2.5%) control had hyperthyroidism. In total, 21 (52.5%) patients and 32 (40%) controls had ≥1 of the features of thyroid disorder, including goiter, positive thyroid autoantibody, and thyroid function abnormality; the difference was not significant (P>0.05). The prevalence of primary thyroid disorders is not significantly increased in patients with CS.http://dx.doi.org/10.1155/2014/732736 |
| spellingShingle | Eda Demir Onal Muhammed Sacikara Fatma Saglam Reyhan Ersoy Bekir Cakir Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study International Journal of Endocrinology |
| title | Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study |
| title_full | Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study |
| title_fullStr | Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study |
| title_full_unstemmed | Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study |
| title_short | Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study |
| title_sort | primary thyroid disorders in patients with endogenous hypercortisolism an observational study |
| url | http://dx.doi.org/10.1155/2014/732736 |
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