PELI2 inhibits colorectal cancer development through MAPK signaling pathway

PELI2 inhibits colorectal cancer development through MAPK signaling pathway

Abstract Colorectal cancer is one of the most common malignant tumors worldwide. Colorectal cancer has a poor survival rate because it tends to metastasise to the liver and other organs. PELI2, an E3 ubiquitin ligase, is down-expressed in a variety of tumors. However, the role of PELI2 in colorectal...

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Bibliographic Details
Main Authors: Jialin Liu, Shengyun Hu, Liangbo Zhao, Yanmei Yang, Guanghua Wu, Yimeng Duan, Xinrui Ma, Peiwen Wang, Zhiyong Zhang, Hong Zong
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Colorectal cancer
PELI2
MAPK
Tumorigenesis
Online Access:https://doi.org/10.1186/s10020-025-01294-3
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