Anti-TGF-β/PD-L1 bispecific antibody synergizes with radiotherapy to enhance antitumor immunity and mitigate radiation-induced pulmonary fibrosis

Anti-TGF-β/PD-L1 bispecific antibody synergizes with radiotherapy to enhance antitumor immunity and mitigate radiation-induced pulmonary fibrosis

Abstract Background Despite the success of immune checkpoint inhibitors (ICIs) in multiple malignant tumors, a significant proportion of patients remain unresponsive to treatment. Radiotherapy (RT) elicits immunogenic antitumor responses but concurrently activates several immune evasion mechanisms....

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Bibliographic Details
Main Authors: Yuze Wu, Yuheng Yan, Yarong Guo, Mengke Niu, Binghan Zhou, Jing Zhang, Pengfei Zhou, Qian Chu, Qi Mei, Ming Yi, Kongming Wu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Hematology & Oncology
Subjects:
Radiotherapy
PD-L1
TGF-β
Bispecific antibody
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13045-025-01678-2
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https://doi.org/10.1186/s13045-025-01678-2

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