Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization

Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization

Background: Observational studies suggest a correlation between mitochondrial DNA copy number (mtDNA-CN) and renal function; however, the causality remains uncertain. This study employed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the genetic causal relationship b...

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Bibliographic Details
Main Authors: Suwei Wang, Yuanjing Yang, Zeyu Pang, Yidan Li, Ke Li, Yan Sun, Jurong Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Mitochondrial DNA copy number
renal function
mendelian randomization
genetic causality
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2542522
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2542522

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