Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice

Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice

ABSTRACT Background A significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations in diabetic cardiomyopathy (DCM). However, the molecular mechanisms underlying mitochondrial FAO impairment in DCM remain to be fully elucidated....

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Main Authors: Qing‐Bo Lu, He‐Ting Sun, Kuo Zhou, Jia‐Bao Su, Xin‐Yu Meng, Guo Chen, Ao‐Yuan Zhang, An‐Jing Xu, Chen‐Yang Zhao, Yuan Zhang, Yao Wang, Hong‐Bo Qiu, Zhuo‐Lin Lv, Zheng‐Yang Bao, Jian Zhu, Feng Xiao, Xue‐Xue Zhu, Hai‐Jian Sun
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
cardiomyopathy
Decr1
diabetes
fatty acid oxidation
oxidative stress
PDK4
Online Access:https://doi.org/10.1002/jcsm.13761
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https://doi.org/10.1002/jcsm.13761

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