Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.

We developed a new statistical framework to find genetic variants associated with extreme longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large studies of age-related disease in order to narrow the search for SNPs associated with longevity. To gain support for our app...

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Bibliographic Details
Main Authors: Kristen Fortney, Edgar Dobriban, Paolo Garagnani, Chiara Pirazzini, Daniela Monti, Daniela Mari, Gil Atzmon, Nir Barzilai, Claudio Franceschi, Art B Owen, Stuart K Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005728&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005728&type=printable

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