Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies

Hydroxychloroquine modulates the progression of experimentally induced benign prostatic hyperplasia in rats via targeting EGFR/ERK/STAT3 and AR/FOXO1/TRAIL pathways: computational and in vivo studies

Abstract Benign prostatic hyperplasia (BPH) is a prevalent progressive age-related disorder in men, yet its etiopathophysiology remains poorly understood. Current treatments like finasteride (Fin) have limited long-term efficacy, necessitating alternative therapies. Hydroxychloroquine (HCQ), a safe...

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Bibliographic Details
Main Authors: Walaa H. El-Maadawy, Ehab Hafiz, Samer A. Tadros, Sally A. Fahim, Haidy M. Ebrahim, Marwa A. Fouad, Yasmin M. Attia
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Benign prostate hyperplasia
Hydroxychloroquine
EGFR
STAT3
FOXO1
TRAIL-mediated apoptosis
Online Access:https://doi.org/10.1038/s41598-025-04267-y
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https://doi.org/10.1038/s41598-025-04267-y

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