RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis

RORα-activated mitophagy attenuating hypoxic-ischemic encephalopathy via suppression of microglial cGAS-STING axis

IntroductionHypoxic-ischemic encephalopathy (HIE) involves neuroinflammation driven by microglial activation, yet regulatory mechanisms remain poorly defined. This study investigates how Retinoic Acid Receptor-Related Orphan Receptor Alpha (RORα) modulates mitophagy to suppress mtDNA-cGAS-STING-NLRP...

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Bibliographic Details
Main Authors: Lei Song, Haiyan Shen, Fei Hong, Weiyan Zhang, Hongyi Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
hypoxic-ischemic encephalopathy
RORα
mitophagy
scRNA-seq
neuroinflammation
cGAS-STING pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592737/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1592737/full

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