Macrophage EP4 Deficiency Drives Atherosclerosis Progression via CD36-Mediated Lipid Uptake and M1 Polarization

Macrophage EP4 Deficiency Drives Atherosclerosis Progression via CD36-Mediated Lipid Uptake and M1 Polarization

Atherosclerosis is a chronic inflammatory disease and a major pathological basis of numerous cardiovascular conditions, with a high global mortality rate. Macrophages play a pivotal role in its pathogenesis through phenotypic switching and foam cell formation. Prostaglandin E2 receptor subtype 4 (EP...

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Bibliographic Details
Main Authors: Xinyu Tang, Qian Chen, Manli Guo, Ying Wen, Cuiping Jia, Yun Bu, Ting Wang, Yuan Zhang, Waiho Tang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
EP4
macrophage polarization
foam cell
CD36
atherosclerosis
Online Access:https://www.mdpi.com/2073-4409/14/13/1021
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