Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

Abstract In murine models of visceral leishmaniasis (VL), the parasitization of resident Kupffer cells (resKCs) drives early Leishmania infantum growth in the liver, leading to granuloma formation and subsequent parasite control. Using the chronic VL model, we demonstrate that polyclonal resKCs redi...

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Main Authors: Gabriela Pessenda, Tiago R. Ferreira, Andrea Paun, Juraj Kabat, Eduardo P. Amaral, Olena Kamenyeva, Pedro Henrique Gazzinelli-Guimaraes, Shehan R. Perera, Sundar Ganesan, Sang Hun Lee, David L. Sacks
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58360-x
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https://doi.org/10.1038/s41467-025-58360-x

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