In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that targets endosymbiotic Wolbachia bacteria from filari...

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Bibliographic Details
Main Authors: Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0007957/2/pntd.0007957.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T071714Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pntd.0007957/2/pntd.0007957.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T071714Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=26802aed652321cc516d670d8c2accf8a111a98bcd5c95515875c5fb9fe7521079b995d1bf12b17bc51db937c6656720c52c7212fcedb1be332e11fe0e6f74891753c66d25d164675bfccc4217322efa8c59e5a5987c8dde3683957c58fd20e057b76ae608b9cc0ef9d38f7ceb291a2358babef22fcbeeb8e7d0ce59b0db783ff7c7341df065ba074d4b8253e98314d45eeac088958938a5986b5a79f5e1a1e8ecb466dec16f27cf542d4b4460357bc09c4c160a6f8437465b5bda927be4a7392adef6691c70fecf206d544e7a9056dd3cff7a542f53b36d3740d9445336f266eb1bccaf144837af84ac4e677b568c9788a3073c46bd95903f454f3a3e1127f4

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