Controlling outer-sphere solvent reorganization energy to turn on or off the function of artificial metalloenzymes

Abstract Metalloenzymes play essential roles in biology. However, unraveling how outer-sphere interactions can be predictably controlled to influence their functions remains a significant challenge. Inspired by Cu enzymes, we demonstrate how variations in the primary, secondary, and outer coordinati...

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Bibliographic Details
Main Authors: Divyansh Prakash, Suchitra Mitra, Simran Sony, Morgan Murphy, Babak Andi, Landon Ashley, Pallavi Prasad, Saumen Chakraborty
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57904-5
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