A species-level identification pipeline for human gut microbiota based on the V3-V4 regions of 16S rRNA

16S rRNA gene sequencing is pivotal for identifying bacterial species in microbiome studies, especially using the V3-V4 hypervariable regions. A fixed 98.5% similarity threshold is often applied for species-level identification, but this approach can cause misclassification due to varying thresholds...

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Bibliographic Details
Main Authors: Min Wang, Tingting Yuan, Jiali Chen, Jing Yang, Ji Pu, Wenchao Lin, Kui Dong, Luqing Zhang, Jiale Yuan, Han Zheng, Yamin Sun, Jianguo Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1553124/full
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