Clinical outcomes of phenotype-guided treatment in group D carbapenemase-producing Enterobacterales bacteremia

Clinical outcomes of phenotype-guided treatment in group D carbapenemase-producing Enterobacterales bacteremia

ABSTRACT International guidance recommends ceftazidime-avibactam for OXA-48-type carbapenemase-producing Enterobacterales (OXA-48-CPE) infections. However, OXA-48-CPE lacking extended spectrum and AmpC β-lactamases may remain susceptible to third-generation cephalosporins (3GC), potentially allowing...

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Bibliographic Details
Main Authors: Jinghao Nicholas Ngiam, Matthew Chung Yi Koh, Nicholas Jian Hao Chan, Jeanette Teo, Ka Lip Chew
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
OXA-48
carbapenemase
carbapenem-resistant
Enterobacterales
outcomes
antibiotic choice
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00273-25
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https://journals.asm.org/doi/10.1128/spectrum.00273-25

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