PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140

PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140

Abstract Background Acute lung injury (ALI) carries significant mortality with limited targeted therapies. Macrophages drive early inflammatory propagation in ALI, exacerbating pulmonary inflammation. While ADP-ribosylation is a dynamic and reversible post-translational modification (PTM) associated...

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Bibliographic Details
Main Authors: Runjie Fan, Rongxing Zhu, Xiangxiu Cao, Shuhui Ye, Fengyi Gao, Yue Wu, Wanxin Yao, Guang Liang, Yanmei Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
PAPR3
Ppia
NF-κB
ALI
Mono-ADP ribosylation
Online Access:https://doi.org/10.1186/s10020-025-01278-3
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https://doi.org/10.1186/s10020-025-01278-3

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