Metabolites from the <i>Dendrobium</i> Endophyte <i>Pseudomonas protegens</i> CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway

Metabolites from the <i>Dendrobium</i> Endophyte <i>Pseudomonas protegens</i> CM-YJ44 Alleviate Insulin Resistance in HepG2 Cells via the IRS1/PI3K/Akt/GSK3β/GLUT4 Pathway

<b>Background/Objectives:</b> Endophytes can produce bioactive metabolites similar to their host plants. CM-YJ44 (<i>Pseudomonas protegens</i> CHA0, 99.24% similarity), an endophyte from <i>Dendrobium officinale</i>, has not yet validated hypoglycemic potential. T...

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Bibliographic Details
Main Authors: Luqi Qin, Yixia Zhou, Bei Fan, Jiahuan Zheng, Rao Diao, Jiameng Liu, Fengzhong Wang
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
<i>Dendrobium</i> endophyte
insulin resistance
PI3K/Akt Pathway
molecular docking
Online Access:https://www.mdpi.com/1424-8247/18/6/817
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