Induction of cellular autophagy impairs TGF-β1-mediated extracellular matrix deposition in primary human knee fibroblasts

Induction of cellular autophagy impairs TGF-β1-mediated extracellular matrix deposition in primary human knee fibroblasts

Aims: To evaluate the role of autophagy in primary knee fibroblasts undergoing myofibroblast differentiation as an in vitro model of arthrofibrosis, a complication after total knee arthroplasty characterized by aberrant intra-articular scar tissue formation and limited range of motion. Methods: We...

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Bibliographic Details
Main Authors: Oliver B. Dilger, Mason F. Carstens, Cole E. Bothun, Ashley N. Payne, Daniel J. Berry, Joaquin Sanchez-Sotelo, Mark E. Morrey, Roman Thaler, Amel Dudakovic, Matthew P. Abdel
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-04-01
Series:Bone & Joint Research
Subjects:
arthrofibrosis
autophagy
total knee arthroplasty (tka)
myofibroblast
extracellular matrix
fibroblasts
transforming growth factor-beta 1
knee
western blotting
amino acids
collagens
quantitative polymerase chain reaction
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.144.BJR-2024-0312.R1
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https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.144.BJR-2024-0312.R1

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