Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure

Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure

Abstract Unresolved tissue damage is a common feature of Inflammatory Bowel Disease (IBD) that facilitates disease progression. Here, we showed that high animal fat diets (HFD), an environmental risk factor associated with IBD pathogenesis, suppress intestinal macrophage production of critical tissu...

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Main Authors: Ashleigh M. Gil, Daniel F. Zegarra-Ruiz, Wan-Jung Wu, Kendra Norwood, Adrien Assie, Buck S. Samuel, Angela M. Major, Gretchen E. Diehl, Andrea A. Hill McAlester
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-12448-y
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https://doi.org/10.1038/s41598-025-12448-y

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