Persistent neutrophilic inflammation is associated with delayed toxicity of phenylarsine oxide in lungs

Persistent neutrophilic inflammation is associated with delayed toxicity of phenylarsine oxide in lungs

Abstract Phenyl arsine oxide (PAO) is a vesicant, similar to Lewisite, a potential chemical warfare agent and an environmental contaminant. PAO-induced skin burns can trigger acute organ injury, including lungs. We have recently demonstrated that PAO burns can have delayed toxicity, although the spe...

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Bibliographic Details
Main Authors: Nilda C. Sanchez, Gopikrishnan Mani, Joanna I. Nowak, Carlin Jones, Young-il Kim, Nirmal S. Sharma, Jaroslaw W. Zmijewski, Ranu Surolia
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Phenyl Arsine oxide
Arsenicals
Neutrophil extracellular traps
IL-33
Persistent inflammation
Airway remodeling
Online Access:https://doi.org/10.1038/s41598-025-95645-z
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https://doi.org/10.1038/s41598-025-95645-z

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