Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy

Neurons, as post–mitotic and long–lived cells, rely heavily on autophagy to maintain cellular homoeostasis and ensure proper function. Huntingtin (HTT), a protein central to Huntington’s disease (HD), has emerged as a putative multifunctional regulator within the neuronal autophagy–lysosome pathway....

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Bibliographic Details
Main Authors: Thomas J. Krzystek, Shermali Gunawardena
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Autophagy Reports
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Online Access:https://www.tandfonline.com/doi/10.1080/27694127.2025.2472450
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