RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells

RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells

Abstract Background RNA-binding proteins (RBPs) are essential in cardiac development. However, a large of them have not been characterized during the process. Methods We applied the human embryonic stem cells (hESCs) differentiated into cardiomyocytes model and constructed SAMD4A-knockdown/overexpre...

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Main Authors: Na Yi, Han-rui Wang, Yu-ping Zhu, Tao Xiao, Qin Lin, Huan Liu, Yi-lei Meng, Yi-zhuo Sun, Fang Lin, Sang-yu Hu, Hua-ming Cao, Jun-fang Zhang, Lu-ying Peng, Li Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
RNA-binding protein
SAMD4A
Cardiomyocyte differentiation
FGF2
FGFR2
Stem cell
Online Access:https://doi.org/10.1186/s13287-025-04269-7
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https://doi.org/10.1186/s13287-025-04269-7

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