Assessment of the Effects of Chemotherapy on Ovarian Reserve in Rats

Assessment of the Effects of Chemotherapy on Ovarian Reserve in Rats

OBJECTIVE: To determine the effect of cyclophosphamide and cisplatin on ovarian reserve in rats by the way of counting primordial follicle and assessing TNF-alpha, 8-OH deguanosine and oxidant/antioxidant status. STUDY DESIGN: Thirty Wistar rats were divided into three groups. Cisplatin was adminis...

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Main Authors: Ahmet Mete Ergenoğlu, Özgür Yeniel, Volkan Turan, Gülşah Demirtaş, Levent Akman, Mustafa Coşan Terek, Gülinnaz Ercan, Osman Zekioğlu
Format: Article
Language:English
Published: Medical Network 2014-04-01
Series:Gynecology Obstetrics & Reproductive Medicine
Subjects:
Chemotherapy
Ovarian reserve
DNA damage
Oxidative stress
Rats
Online Access:https://gorm.com.tr/index.php/GORM/article/view/126
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