A live‐attenuated pneumococcal vaccine elicits CD4+ T‐cell dependent class switching and provides serotype independent protection against acute otitis media

A live‐attenuated pneumococcal vaccine elicits CD4+ T‐cell dependent class switching and provides serotype independent protection against acute otitis media

Abstract Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as...

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Bibliographic Details
Main Authors: Jason W Rosch, Amy R Iverson, Jessica Humann, Beth Mann, Geli Gao, Peter Vogel, Michael Mina, Kyle A Murrah, Antonia C Perez, W Edward Swords, Elaine I Tuomanen, Jonathan A McCullers
Format: Article
Language:English
Published: Springer Nature 2013-11-01
Series:EMBO Molecular Medicine
Subjects:
otitis media
Streptococcus
vaccine
virulence
Online Access:https://doi.org/10.1002/emmm.201202150
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https://doi.org/10.1002/emmm.201202150

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