Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury

Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury

The present study was designed to investigate the role of Schwann cell (SC) Piezo1 in peripheral nociception. We first developed an AAV vector that has primary SC tropism after delivery into the sciatic (or tibial) nerve. This was achieved by packing AAV-GFP transcribed by a CBA promoter using a cap...

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Bibliographic Details
Main Authors: Brandon Itson-Zoske, Uarda Gani, Alexander Mikesell, Chensheng Qiu, Fan Fan, Cheryl L. Stucky, Quinn H. Hogan, Seung Min Shin, Hongwei Yu
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
Piezo1
peripheral nervous system
Schwann cells
AAVolig001
neuropathic pain
intraneural injection
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000282
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http://www.sciencedirect.com/science/article/pii/S2329050125000282

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