Case report of hypercalcemia-related kidney complications after discontinuation of denosumab

Case report of hypercalcemia-related kidney complications after discontinuation of denosumab

BackgroundThe use of the osteoclastogenesis inhibitor denosumab is increasing in pediatrics, especially in the treatment of giant cell tumor or granuloma of bone or jaw, aneurysmal bone cyst, and other rare bone disorders. Particularly in pediatric patients, adverse kidney effects—such as acute kidn...

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Bibliographic Details
Main Authors: Gerrit van den Berg, Marc R. Lilien, Rutger R. G. Knops, Robert J. J. van Es, Atty T. H. van Dijk, Mandy G. Keijzer-Veen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pediatrics
Subjects:
denosumab
acute kidney injury
hypercalcemia
case report
pediatric nephrology
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1583240/full
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https://www.frontiersin.org/articles/10.3389/fped.2025.1583240/full

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