Redox-sensitive camptothecin prodrug: A promising drug delivery strategy with ultrahigh drug loading and tunable drug release

Redox-sensitive camptothecin prodrug: A promising drug delivery strategy with ultrahigh drug loading and tunable drug release

Small molecular drugs play a critical role in cancer therapy but face challenges like poor solubility, severe side effects, and inefficient delivery. Polymeric micellar-based drug delivery systems show promise but struggle with low drug loading, instability, and premature drug release partly due to...

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Bibliographic Details
Main Authors: Shiwei Fu, Vanessa Puche, Bowen Zhao, Xiao Zhang, Victoria A.A. McKenzie, Sophia Garcia, Fuwu Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Nano TransMed
Subjects:
Camptothecin
Chemotherapeutic agent
Drug delivery
Nanomedicine
Ultrahigh drug loading
Online Access:http://www.sciencedirect.com/science/article/pii/S2790676025000196
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