Collagen I Microfiber Promotes Brain Capillary Network Formation in Three–Dimensional Blood–Brain Barrier Microphysiological Systems

Collagen I Microfiber Promotes Brain Capillary Network Formation in Three–Dimensional Blood–Brain Barrier Microphysiological Systems

Background: The blood–brain barrier (BBB) strictly regulates the penetration of substances into the brain, which, although important for maintaining brain homeostasis, may delay drug development because of the difficulties in predicting pharmacokinetics/pharmacodynamics (PKPD), toxicokinetics/toxico...

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Bibliographic Details
Main Authors: Kimiko Nakayama-Kitamura, Yukari Shigemoto-Mogami, Marie Piantino, Yasuhiro Naka, Asuka Yamada, Shiro Kitano, Tomomi Furihata, Michiya Matsusaki, Kaoru Sato
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biomedicines
Subjects:
blood–brain barrier (bbb)
microphysiological system (MPS)
collagen I microfiber (CMF)
integrin
humanized model
Online Access:https://www.mdpi.com/2227-9059/12/11/2500
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