Evolutionary Trajectories of Methionine Metabolism in Mycobacterium and Its Application to Engineer a Vitamin B12 Whole‐Cell Ribosensor

Evolutionary Trajectories of Methionine Metabolism in Mycobacterium and Its Application to Engineer a Vitamin B12 Whole‐Cell Ribosensor

ABSTRACT Vitamin B12 metabolism differs among members of the Mycobacterium genus. While non‐tuberculous mycobacterial species are B12 producers, tuberculous mycobacteria lack endogenous production and rely on the host supply of this vitamin. Here, we hypothesise that this discrepant phenotype might...

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Main Authors: Elena Campos‐Pardos, Laura Sanz‐Asensio, Sandra Pérez‐Jiménez, Inmaculada Yruela, Bruno Contreras‐Moreira, Alejandro Toledo‐Arana, Jesús Gonzalo‐Asensio
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Microbial Biotechnology
Subjects:
B12 metabolism
cobalamin
methionine biosynthesis
Mycobacterium tuberculosis complex
non‐tuberculous mycobacteria
Online Access:https://doi.org/10.1111/1751-7915.70176
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https://doi.org/10.1111/1751-7915.70176

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