Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway

Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway

Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), and effective therapies are still lacking. Reactive oxygen species (ROS) stress induces NLRP3 inflammasome activation, and this, along with extracellular matrix metabolism (ECM) degradation in nucleus pulposus cells (NPC...

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Bibliographic Details
Main Authors: Tu Yiting, Ren Jiaping, Fang Weiyuan, Zhou Chencheng, Zhao Binli, Hua Tianyong, Chen Yiqi, Chen Zhenya, Feng Yongzeng, Jin Haiming, Wang Xiangyang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2025-01-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
daphnetin
IDD
mitophagy
extracellular matrix
NLRP3 inflammasome
Nrf2/PINK1
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2025002
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https://www.sciengine.com/doi/10.3724/abbs.2025002

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