MacroD1 sustains mitochondrial integrity and oxidative metabolism

MacroD1 sustains mitochondrial integrity and oxidative metabolism

Abstract The mono-ADP-ribosylhydrolase MacroD1 has been recently reported to localize to mitochondria exclusively. However, the extent and means by which MacroD1 regulates metabolic homeostasis remains unclear. Here we show that the absence of MacroD1 in mice decreased mitochondrial load and negativ...

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Main Authors: Ann-Katrin Hopp, Lorenza P. Ferretti, Lisa Schlicker, Amalia Ruiz-Serrano, Udo Hetzel, Francesco Prisco, Anja Kipar, Lukas Muskalla, Elena Ferrari, Carsten C. Scholz, Karsten Hiller, Francisco Verdeguer, Deena M. Leslie Pedrioli, Michael O. Hottiger
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62410-9
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https://doi.org/10.1038/s41467-025-62410-9

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