Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model

Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene. This leads to progressive loss of striatal neurons and motor-cognitive decline. While current gene-targeting approaches aiming at reducing somatic instability show promise – especially i...

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Main Authors: Linda Scaramuzza, Marta Ribodino, Christian Cassarino, Marta Morrocchi, Gabriela B Gomez Gonzalez, Roberta Parolisi, Edoardo Sozzi, Giacomo Turrini, Valentina Cerrato, Paola Conforti, Eriola Hoxha, Riccardo Tognato, Greta Galeotti, Chiara Cordiglieri, Maria Cristina Crosti, Stefano Zucca, Martina Lorenzati, Serena Bovetti, Paolo Spaiardi, Claudio de’Sperati, Gerardo Biella, Linda Ottoboni, Malin Parmar, Simone Maestri, Dario Besusso, Elena Cattaneo, Annalisa Buffo
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Pharmacological Research
Subjects:
Stem cell therapy
Neurodegeneration
Huntington’s disease
Cell transplantation
MSN (Medium Spiny Neurons)
Striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003305
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