A Base Pair Outside the Catalytic Core of the I-R3 DNA Enzyme Has a Significant Effect on Its Cleavage Activity: An Improved Catalytic Core Model and an Automated Design Program
The I-R3 DNA enzyme, in its trans-acting form, is capable of cleaving single-stranded DNA (ssDNA) molecules. We have collected all published information on the activity levels of the original I-R3 DNA enzyme and its known variants and embedded that information into a program (we called IR3). The pro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.1155/jna/5518018 |
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