Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus
Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to i...
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2023-05-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/1039 |
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| author | A. S. Tyulyandina E. A. Ulrikh L. A. Kolomiets S. E. Krasilnikov A. G. Kedrova A. A. Rumyantsev G. A. Raskin A. I. Nesterova M. V. Volkonskiy O. N. Churuksaeva A. Yu. Goryainova V. V. Zhavoronkova V. N. Dmitriev S. T. Nazranova A. V. Shkradyuk K. S. Volkova A. I. Arutyunova S. N. Kunitskaya L. V. Stepura T. G. Zolotoreva E. B. Shakhnovich E. V. Ponomareva M. A. Strokova A. S. Danilova E. S. Martynova |
| author_facet | A. S. Tyulyandina E. A. Ulrikh L. A. Kolomiets S. E. Krasilnikov A. G. Kedrova A. A. Rumyantsev G. A. Raskin A. I. Nesterova M. V. Volkonskiy O. N. Churuksaeva A. Yu. Goryainova V. V. Zhavoronkova V. N. Dmitriev S. T. Nazranova A. V. Shkradyuk K. S. Volkova A. I. Arutyunova S. N. Kunitskaya L. V. Stepura T. G. Zolotoreva E. B. Shakhnovich E. V. Ponomareva M. A. Strokova A. S. Danilova E. S. Martynova |
| author_sort | A. S. Tyulyandina |
| collection | DOAJ |
| description | Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to identify patients at high risk of Lynch syndrome, evaluate the disease prognosis, and estimate the efficacy of immune checkpoint inhibitors and their combinations. This review details current concepts of MSI diagnostics and discusses its predictive value in patients with endometrial cancer. It also describes a new diagnostic algorithm for the detection of dMMR and MSI. |
| format | Article |
| id | doaj-art-dd56d4fb73f4467fa248768ea1bf41c3 |
| institution | Kabale University |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj-art-dd56d4fb73f4467fa248768ea1bf41c32025-08-20T04:00:08ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272023-05-0118413814610.17650/1994-4098-2022-18-4-138-146757Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensusA. S. Tyulyandina0E. A. Ulrikh1L. A. Kolomiets2S. E. Krasilnikov3A. G. Kedrova4A. A. Rumyantsev5G. A. Raskin6A. I. Nesterova7M. V. Volkonskiy8O. N. Churuksaeva9A. Yu. Goryainova10V. V. Zhavoronkova11V. N. Dmitriev12S. T. Nazranova13A. V. Shkradyuk14K. S. Volkova15A. I. Arutyunova16S. N. Kunitskaya17L. V. Stepura18T. G. Zolotoreva19E. B. Shakhnovich20E. V. Ponomareva21M. A. Strokova22A. S. Danilova23E. S. Martynova24N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Petrov National Medical Research Institute of Oncology, Ministry of Health of Russia; I.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaResearch Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of SciencesInstitute of Oncology and Neurosurgery, E.N. Meshalkin National Medical Research Center, Ministry of Health of RussiaDepartment of Oncology, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian Federation; Department of Obstetrics and Gynecology, Academy of Postgraduate Education, Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of the Russian FederationN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaSaint Petersburg State University; Medical and Diagnostic Center of S. Berezin International Institute of Biological SystemsRepublican Clinical Oncology Dispensary, Ministry of Health of the Republic of Tatarstan; Kazan Federal UniversityMoscow City Oncology Hospital No. 62, Moscow Healthcare DepartmentResearch Institute of Oncology, Tomsk National Research Medical Center, Russian Academy of SciencesClinical Oncology Dispensary No. 1; Kuban State Medical UniversityVolgograd Regional Clinical Oncology Dispensary; Volgograd State Medical University, Ministry of Health of RussiaBelgorod National Research University; Belgorod Oncology DispensaryOncology Dispensary, Ministry of Health of Kabardino-Balkar RepublicV.M. Efetov Crimean Republican Oncology Clinical DispensarySamara Regional Clinical Oncology DispensaryPyatigorsk Regional Oncology DispensaryV.M. Efetov Crimean Republican Oncology Clinical DispensaryOncology Dispensary in ShakhtySamara Regional Clinical Oncology DispensaryKorolev City HospitalV.M. Efetov Crimean Republican Oncology Clinical DispensaryV.M. Efetov Crimean Republican Oncology Clinical DispensaryMoscow City Oncology Hospital No. 62, Moscow Healthcare DepartmentA.I. Kryzhanovsky Krasnoyarsk Regional Clinical Oncology DispensaryDeficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to identify patients at high risk of Lynch syndrome, evaluate the disease prognosis, and estimate the efficacy of immune checkpoint inhibitors and their combinations. This review details current concepts of MSI diagnostics and discusses its predictive value in patients with endometrial cancer. It also describes a new diagnostic algorithm for the detection of dMMR and MSI.https://ojrs.abvpress.ru/ojrs/article/view/1039deficient dna mismatch repairmicrosatellite instabilityimmunotherapyendometrial canceruterine cancerpembrolizumablenvatinib |
| spellingShingle | A. S. Tyulyandina E. A. Ulrikh L. A. Kolomiets S. E. Krasilnikov A. G. Kedrova A. A. Rumyantsev G. A. Raskin A. I. Nesterova M. V. Volkonskiy O. N. Churuksaeva A. Yu. Goryainova V. V. Zhavoronkova V. N. Dmitriev S. T. Nazranova A. V. Shkradyuk K. S. Volkova A. I. Arutyunova S. N. Kunitskaya L. V. Stepura T. G. Zolotoreva E. B. Shakhnovich E. V. Ponomareva M. A. Strokova A. S. Danilova E. S. Martynova Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus Опухоли женской репродуктивной системы deficient dna mismatch repair microsatellite instability immunotherapy endometrial cancer uterine cancer pembrolizumab lenvatinib |
| title | Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus |
| title_full | Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus |
| title_fullStr | Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus |
| title_full_unstemmed | Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus |
| title_short | Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus |
| title_sort | microsatellite instability in endometrial cancer the role of diagnostic methods and their clinical application expert consensus |
| topic | deficient dna mismatch repair microsatellite instability immunotherapy endometrial cancer uterine cancer pembrolizumab lenvatinib |
| url | https://ojrs.abvpress.ru/ojrs/article/view/1039 |
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