Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus

Microsatellite instability in endometrial cancer: the role of diagnostic methods and their clinical application. Expert consensus

Deficient DNA mismatch repair (dMMR) is a rare molecular disorder found in 20-30 % of endometrial tumors. Laboratory identification of dMMR/microsatellite instability (MSI) has a high diagnostic value, since these impairments are considered as biomarkers of endometrial adenocarcinoma. They help to i...

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Main Authors: A. S. Tyulyandina, E. A. Ulrikh, L. A. Kolomiets, S. E. Krasilnikov, A. G. Kedrova, A. A. Rumyantsev, G. A. Raskin, A. I. Nesterova, M. V. Volkonskiy, O. N. Churuksaeva, A. Yu. Goryainova, V. V. Zhavoronkova, V. N. Dmitriev, S. T. Nazranova, A. V. Shkradyuk, K. S. Volkova, A. I. Arutyunova, S. N. Kunitskaya, L. V. Stepura, T. G. Zolotoreva, E. B. Shakhnovich, E. V. Ponomareva, M. A. Strokova, A. S. Danilova, E. S. Martynova
Format: Article
Language:Russian
Published: ABV-press 2023-05-01
Series:Опухоли женской репродуктивной системы
Subjects:
deficient dna mismatch repair
microsatellite instability
immunotherapy
endometrial cancer
uterine cancer
pembrolizumab
lenvatinib
Online Access:https://ojrs.abvpress.ru/ojrs/article/view/1039
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