Somatic cell reprogramming from different origins and donors into iPSC, with four factors OSKM using viral Sendai vectors

Somatic cell reprogramming from different origins and donors into iPSC, with four factors OSKM using viral Sendai vectors

Notocordal-like cells (NLCs) produced from hiPSCs is considered as a promising candidate for cell-based regenerative therapies to treat intervertebral disk degeneration (IVDD). However, OCT4, SOX2, KLF4, C-MYC (OSKM) reprogramming into iPSC was described to maintain (epi)genomic hallmarks of the ori...

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Main Authors: Romain Desprat, Mikael Magnano, Paul Bensadoun, Mathis Soubeyrand, Patrick Callier, Quentin Alle, Anaelle Bailly, Benjamin Gantenbein, Lisanne T. Laagland, Mariana Tryfonidou, Jerome Guicheux, Anne Camus, Ollivier Milhavet, Jean-Marc Lemaitre
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506125000868
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