The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice

Abstract Alzheimer’s disease (AD) is characterized by amyloid plaques, neurofibrillary tangles, and synaptic and neuronal loss. Recently, a rare autosomal dominant coding mutation, T835M, in the Un-coordinated 5c (UNC5C) netrin receptor gene was segregated with late-onset AD (LOAD). Overexpression o...

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Main Authors: Devi Krishna Priya Karunakaran, Makenna Ley, Joanna Guo, Ammaarah Khatri, Katherine Sadleir, Jelena Popovic, Arun Kumar Upadhyay, Jeffrey Savas, Daniele Procissi, Jasvinder Atwal, Robert Vassar
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Neurodegeneration
Online Access:https://doi.org/10.1186/s13024-025-00850-z
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https://doi.org/10.1186/s13024-025-00850-z

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