Advances in PIWI-piRNA function in female reproduction in mammals
PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced <sc>silencing</sc> complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductiv...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-11-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024195 |
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| _version_ | 1832590361609895936 |
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| author | Lv Xiaolong Zhang Hongdao Wu Ligang |
| author_facet | Lv Xiaolong Zhang Hongdao Wu Ligang |
| author_sort | Lv Xiaolong |
| collection | DOAJ |
| description | PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced <sc>silencing</sc> complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation. In particular, studies of piRNA expression dynamics, functional <sc>redundancies</sc>, and compositional variations across mammal species have advanced our understanding of piRNA functions in male and, especially, female reproduction. These findings further support the use of hamsters as a more representative model of piRNA biology in mammals. In addition to discussing these new perspectives, the current review also covers emerging directions for piRNA research, its implications for female fertility, and our fundamental understanding of reproductive mechanisms. |
| format | Article |
| id | doaj-art-dd38545ec1f246e89918edb7dff4d51e |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-dd38545ec1f246e89918edb7dff4d51e2025-01-24T00:56:48ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-11-015714815610.3724/abbs.202419520d259ccAdvances in PIWI-piRNA function in female reproduction in mammalsLv Xiaolong0Zhang Hongdao1Wu Ligang2[][][]PIWI-interacting RNAs (piRNAs), which associate with PIWI clade Argonaute proteins to form piRNA-induced <sc>silencing</sc> complexes (piRISCs) in germline cells, are responsible for maintaining genomic integrity and reproductive function through transcriptional or post-transcriptional suppression of transposable elements and regulation of protein-coding genes. Recent discoveries of crucial PIWI-piRNA functions in oogenesis and embryogenesis in golden hamsters suggest an indispensable role in female fertility that has been obscured in the predominant mouse model of PIWI-piRNA pathway regulation. In particular, studies of piRNA expression dynamics, functional <sc>redundancies</sc>, and compositional variations across mammal species have advanced our understanding of piRNA functions in male and, especially, female reproduction. These findings further support the use of hamsters as a more representative model of piRNA biology in mammals. In addition to discussing these new perspectives, the current review also covers emerging directions for piRNA research, its implications for female fertility, and our fundamental understanding of reproductive mechanisms.https://www.sciengine.com/doi/10.3724/abbs.2024195piRNAPIWItransposonoocytesfertility |
| spellingShingle | Lv Xiaolong Zhang Hongdao Wu Ligang Advances in PIWI-piRNA function in female reproduction in mammals Acta Biochimica et Biophysica Sinica piRNA PIWI transposon oocytes fertility |
| title | Advances in PIWI-piRNA function in female reproduction in mammals |
| title_full | Advances in PIWI-piRNA function in female reproduction in mammals |
| title_fullStr | Advances in PIWI-piRNA function in female reproduction in mammals |
| title_full_unstemmed | Advances in PIWI-piRNA function in female reproduction in mammals |
| title_short | Advances in PIWI-piRNA function in female reproduction in mammals |
| title_sort | advances in piwi pirna function in female reproduction in mammals |
| topic | piRNA PIWI transposon oocytes fertility |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024195 |
| work_keys_str_mv | AT lvxiaolong advancesinpiwipirnafunctioninfemalereproductioninmammals AT zhanghongdao advancesinpiwipirnafunctioninfemalereproductioninmammals AT wuligang advancesinpiwipirnafunctioninfemalereproductioninmammals |