Cyclic di-AMP alleviates periodontitis by activating PI3K/Akt/Nrf2 pathways

Cyclic di-AMP alleviates periodontitis by activating PI3K/Akt/Nrf2 pathways

Emerging research demonstrates the regulatory effects of c-di-AMP, a bacterial-derived small molecule secondary messenger, on host immune responses and promoting resistance against infection-related diseases. This study aims to elucidate the role of c-di-AMP in the occurrence and development of peri...

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Bibliographic Details
Main Authors: Kaihua Luo, Qinrui Wu, Zhengyi Li, Yajie Wu, Zhifei Su, Fangjie Zhou, Qinyang Li, Biao Ren, Yuqing Li, Jiyao Li, Xian Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
c-di-AMP
PI3K/Akt signaling pathway
second-messenger systems
periodontitis
host-pathogen interactions
microbial dysbiosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1560155/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1560155/full

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