Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects

Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects

IntroductionThe brain uses ketones, mainly 3-hydroxybutyrate (3-HB), as an alternative energy source. Therefore, oral intake of 3-HB may help maintain brain health. Previous studies indicated that achieving a maximum concentration (Cmax) of 3-HB in plasma at 0.28 mM could initiate ketone metabolism...

Full description

Saved in:

Bibliographic Details
Main Authors:	Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Nutrition
Subjects:	ketone 3-hydroxybutyrate beta-hydroxybutyrate brain energy cognitive function mood
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2024.1470331/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Neuroregeneration Improved by Sodium-D,L-Beta-Hydroxybutyrate in Primary Neuronal Cultures
by: Csilla Ari, et al.
Published: (2024-08-01)

Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer
by: Chase Garcia, et al.
Published: (2025-07-01)

Ketone Body Induction: Insights into Metabolic Disease Management
by: Byung Min Yoo, et al.
Published: (2025-06-01)

Association of circulating ketone bodies with cognitive performance and dementia in the Multi‐Ethnic Study of Atherosclerosis (MESA)
by: Parag Anilkumar Chevli, et al.
Published: (2024-10-01)

Plasticization of poly(3-hydroxybutyrate) with biobased terpenoid esters of geraniol
by: Juan Ivorra-Martinez, et al.
Published: (2023-08-01)

Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering
by: Dariš Barbara, et al.
Published: (2020-03-01)

3-Hydroxybutyrate alleviates septic liver injury by promoting macrophage polarization from M1 to M2
by: Hu Jingjuan, et al.
Published: (2024-12-01)

β-Hydroxybutyrate Protects Against Cisplatin-Induced Renal Damage via Regulating Ferroptosis
by: Ruixue Tian, et al.
Published: (2024-12-01)

Biodegradable conductive composites of poly(3-hydroxybutyrate) and polyaniline nanofibers: Preparation, characterization and radiolytic effects
Published: (2011-01-01)

Lightweight and high performance nano-cellular poly(lactic acid)/poly(3-hydroxybutyrate-co-4-hydroxybutyrate) foams characterized by high volume expansion ratio
by: Yan Wang, et al.
Published: (2025-09-01)

Plasma Beta-Hydroxybutyrate and All-Cause Mortality in Patients with Liver Cirrhosis
by: Mateo Chvatal-Medina, et al.
Published: (2025-05-01)

Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals
by: Manlan Guo, et al.
Published: (2025-03-01)

Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bodies and Relevance of HMGCS2 to Health and Disease
by: Varshini V. Suresh, et al.
Published: (2025-04-01)

Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: current progress and future perspectives
by: Junle Li, et al.
Published: (2025-03-01)

Ultrasonic Molding of Poly(3-hydroxybutyrate) and Its Clay Nanocomposites: Efficient Microspecimens Production with Minimal Material Loss and Degradation
by: Germán Pérez, et al.
Published: (2024-12-01)

Production of Poly(3-hydroxybutyrate-<i>co</i>-3-hydroxyvalerate) (PHBV) by <i>Haloferax mediterranei</i> Using Candy Industry Waste as Raw Materials
by: Lorena Simó-Cabrera, et al.
Published: (2024-08-01)

Effects of frozen storage time on bovine serum and plasma concentrations of macrominerals and indicators of energy balance
by: A. Valldecabres, et al.
Published: (2025-05-01)

Heart ketone metabolism under acute ketone supplementation in ZDF rats, a type 2 diabetes heart failure model
by: Etienne Croteau, et al.
Published: (2025-03-01)

CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via &beta;-Hydroxybutyrate Suppression in Mouse Colonic Epithelium
by: Huang S, et al.
Published: (2025-05-01)

Blends of ethylene-co-vinyl acetate and poly(3-hydroxybutyrate) with adhesion property
by: A. de Lucas-Freile, et al.
Published: (2018-07-01)

β-hydroxybutyrate, a ketone body, suppresses tumor growth, stemness, and invasive phenotypes in non-small cell lung cancer
by: Yunlong Huang, et al.
Published: (2025-12-01)

Improvement of biocompatibility of high molecular weight poly-3-hydroxybutyrate by blending with its functionalized oligomers
by: Anatoly N. Boyandin, et al.
Published: (2024-01-01)

Controlled release profiles of dipyridamole from biodegradable microspheres on the base of poly(3-hydroxybutyrate).
Published: (2007-12-01)

Metabolic Disorders in Delirious Syndrome in Patients with Acute Poisoning with Gamma-Hydroxybutyric Acid and its Precursor
by: A. G. Sinenchenko, et al.
Published: (2020-10-01)

3-Hydroxybutyrate, a metabolite in sustaining neuronal cell vitality: a mendelian randomization and in vitro experimentation
by: Xiaoling Hu, et al.
Published: (2025-07-01)

Structural characteristics and enhanced mechanical and thermal properties of full biodegradable tea polyphenol/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite films
by: M. F. Zhu, et al.
Published: (2013-09-01)

Chronic stress inhibits weight gain and decreases beta-hydroxybutyrate levels and glucose tolerance in female BALB/c fed a high-fat ketogenic diet
by: Ana L. Cantú-Ruiz, et al.
Published: (2025-07-01)

THE RESEARCH OF OSTEOPLASTIC PROPERTIES OF RESORBABLE POLY-3-HYDROXYBUTYRATE IN vIvO ON MODELS OF SEGMENTAL OSTEOTOMY
by: E. I. Shishatskaya, et al.
Published: (2017-01-01)

Development of Chitosan-Coated Electrospun Poly(3-hydroxybutyrate) Biohybrid Materials for Growth and Long-Term Storage of <i>Bacillus subtilis</i>
by: Vladimir Krastev, et al.
Published: (2024-11-01)

Beta-hydroxybutyrate counteracts the deleterious effects of a saturated high-fat diet on synaptic AMPAR receptors and cognitive performance
by: Rocío Rojas, et al.
Published: (2025-09-01)

Towards Precision Nutrition: A Novel Smartphone-Connected Biosensor for Point-of-Care Detection of β-Hydroxybutyrate in Human Blood and Saliva
by: Cristina Tortolini, et al.
Published: (2025-07-01)

Electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds – a step towards ligament repair applications
by: Thammarit Khamplod, et al.
Published: (2022-12-01)

Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights
by: Wenchao Wei, et al.
Published: (2025-03-01)

Substitution of non-forage fibre sources for cereal grains and molasses in calf starter on performance and development of ruminal function
by: D.B. Vagnoni, et al.
Published: (2021-05-01)

A ketogenic diet regulates microglial activation to treat drug addiction
by: Jie Ji, et al.
Published: (2025-01-01)

Pemafibrate ameliorates renal injury through induction of FGF21 and ketone body production in male mice
by: Kunihiko Takahara, et al.
Published: (2025-02-01)

Influence of accelerated weathering on the physical and structural properties of poly(lactic-acid)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PLA/PHBV) blends
by: A. Antunes, et al.
Published: (2021-08-01)

Cardiometabolic disorders affect myocardial [18F]fluorodeoxyglucose uptake– impact on diagnostic PET/CT imaging
by: Suvi Hartikainen, et al.
Published: (2025-07-01)

The Acute Patient Physiologic and Laboratory Evaluation Score and Other Prognostic Factors in Dogs With Diabetic Ketoacidosis
by: Sarah M. Edwards, et al.
Published: (2025-03-01)

An HPLC-MS/MS method for the quantification of heat stress-related milk metabolites in milk from Holstein-Friesian cross-bred cows in Tanzania
by: V Habimana, et al.
Published: (2025-03-01)