Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects

Optimizing oral 3-hydroxybutyrate dosage using pharmacokinetic model to improve cognitive function and mood in healthy subjects

IntroductionThe brain uses ketones, mainly 3-hydroxybutyrate (3-HB), as an alternative energy source. Therefore, oral intake of 3-HB may help maintain brain health. Previous studies indicated that achieving a maximum concentration (Cmax) of 3-HB in plasma at 0.28 mM could initiate ketone metabolism...

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Main Authors: Kentaro Nishioka, Takahiro Ishimoto, Mariko Sato, Ruki Yasuda, Yumi Nakamura, Hiroshi Watanabe, Toshihide Suzuki, Yudai Araragi, Yukio Kato, Ken-ichi Yoshida, Norihito Murayama
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Nutrition
Subjects:
ketone
3-hydroxybutyrate
beta-hydroxybutyrate
brain energy
cognitive function
mood
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2024.1470331/full
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https://www.frontiersin.org/articles/10.3389/fnut.2024.1470331/full

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