Breaking up prolonged sedentary behavior to improve cardiometabolic health (BREAK2): protocol for a dose-finding adaptive randomization trial

Breaking up prolonged sedentary behavior to improve cardiometabolic health (BREAK2): protocol for a dose-finding adaptive randomization trial

Abstract Background Excessive sedentary behavior is highly prevalent in developed nations and is a risk factor for cardiovascular disease (CVD) morbidity and mortality. As such, health agencies have provided general recommendations to “sit less, move more” by interspersing brief periods of activity....

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Main Authors: Keith M. Diaz, Margaret E. Murdock, Adriana Wu Clark, Sitara Kumar, Victor Jerez, Maria A. Serafini, Chang Xu, Benjamin D. Boudreaux, Emily K. Romero, Jennifer Aguirre, Heather Seid, Renu Nandakumar, Henry Ginsberg, Daichi Shimbo, Ying Kuen Cheung
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Public Health
Subjects:
Sedentary behavior
Cardiometabolic health
Randomized crossover trial
Dose-response
Adaptive randomization
Prolonged sitting
Online Access:https://doi.org/10.1186/s12889-025-22250-0
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https://doi.org/10.1186/s12889-025-22250-0

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