Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma

Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma

Abstract MYC is a key oncogenic driver in multiple tumor types, but concomitantly endows cancer cells with a series of vulnerabilities that provide opportunities for targeted pharmacological intervention. For example, drugs that suppress mitochondrial respiration selectively kill MYC‐overexpressing...

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Main Authors: Giulio Donati, Paola Nicoli, Alessandro Verrecchia, Veronica Vallelonga, Ottavio Croci, Simona Rodighiero, Matteo Audano, Laura Cassina, Aya Ghsein, Giorgio Binelli, Alessandra Boletta, Nico Mitro, Bruno Amati
Format: Article
Language:English
Published: Springer Nature 2023-05-01
Series:EMBO Molecular Medicine
Subjects:
lymphoma
mitochondria
MYC
ROS
targeted therapy
Online Access:https://doi.org/10.15252/emmm.202216910
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https://doi.org/10.15252/emmm.202216910

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