Quantitative PET imaging and modeling of molecular blood-brain barrier permeability
Abstract Neuroimaging of blood-brain barrier permeability has been instrumental in identifying its broad involvement in neurological and systemic diseases. However, current methods evaluate the blood-brain barrier mainly as a structural barrier. Here we developed a non-invasive positron emission tom...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58356-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850208068787240960 |
|---|---|
| author | Kevin J. Chung Yasser G. Abdelhafez Benjamin A. Spencer Terry Jones Quyen Tran Lorenzo Nardo Moon S. Chen Souvik Sarkar Valentina Medici Victoria Lyo Ramsey D. Badawi Simon R. Cherry Guobao Wang |
| author_facet | Kevin J. Chung Yasser G. Abdelhafez Benjamin A. Spencer Terry Jones Quyen Tran Lorenzo Nardo Moon S. Chen Souvik Sarkar Valentina Medici Victoria Lyo Ramsey D. Badawi Simon R. Cherry Guobao Wang |
| author_sort | Kevin J. Chung |
| collection | DOAJ |
| description | Abstract Neuroimaging of blood-brain barrier permeability has been instrumental in identifying its broad involvement in neurological and systemic diseases. However, current methods evaluate the blood-brain barrier mainly as a structural barrier. Here we developed a non-invasive positron emission tomography method in humans to measure the blood-brain barrier permeability of molecular radiotracers that cross the blood-brain barrier through its molecule-specific transport mechanism. Our method uses high-temporal resolution dynamic imaging and kinetic modeling for multiparametric imaging and quantification of the blood-brain barrier permeability-surface area product of molecular radiotracers. We show, in humans, our method can resolve blood-brain barrier permeability across three radiotracers and demonstrate its utility in studying brain aging and brain-body interactions in metabolic dysfunction-associated steatotic liver inflammation. Our method opens new directions to effectively study the molecular permeability of the human blood-brain barrier in vivo using the large catalogue of available molecular positron emission tomography tracers. |
| format | Article |
| id | doaj-art-dd058e60c6d14e07ba42a1f97103dd98 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-dd058e60c6d14e07ba42a1f97103dd982025-08-20T02:10:19ZengNature PortfolioNature Communications2041-17232025-03-0116111710.1038/s41467-025-58356-7Quantitative PET imaging and modeling of molecular blood-brain barrier permeabilityKevin J. Chung0Yasser G. Abdelhafez1Benjamin A. Spencer2Terry Jones3Quyen Tran4Lorenzo Nardo5Moon S. Chen6Souvik Sarkar7Valentina Medici8Victoria Lyo9Ramsey D. Badawi10Simon R. Cherry11Guobao Wang12Department of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Internal Medicine, University of California Davis HealthDepartment of Internal Medicine, University of California Davis HealthDepartment of Internal Medicine, University of California Davis HealthDepartment of Surgery, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthDepartment of Radiology, University of California Davis HealthAbstract Neuroimaging of blood-brain barrier permeability has been instrumental in identifying its broad involvement in neurological and systemic diseases. However, current methods evaluate the blood-brain barrier mainly as a structural barrier. Here we developed a non-invasive positron emission tomography method in humans to measure the blood-brain barrier permeability of molecular radiotracers that cross the blood-brain barrier through its molecule-specific transport mechanism. Our method uses high-temporal resolution dynamic imaging and kinetic modeling for multiparametric imaging and quantification of the blood-brain barrier permeability-surface area product of molecular radiotracers. We show, in humans, our method can resolve blood-brain barrier permeability across three radiotracers and demonstrate its utility in studying brain aging and brain-body interactions in metabolic dysfunction-associated steatotic liver inflammation. Our method opens new directions to effectively study the molecular permeability of the human blood-brain barrier in vivo using the large catalogue of available molecular positron emission tomography tracers.https://doi.org/10.1038/s41467-025-58356-7 |
| spellingShingle | Kevin J. Chung Yasser G. Abdelhafez Benjamin A. Spencer Terry Jones Quyen Tran Lorenzo Nardo Moon S. Chen Souvik Sarkar Valentina Medici Victoria Lyo Ramsey D. Badawi Simon R. Cherry Guobao Wang Quantitative PET imaging and modeling of molecular blood-brain barrier permeability Nature Communications |
| title | Quantitative PET imaging and modeling of molecular blood-brain barrier permeability |
| title_full | Quantitative PET imaging and modeling of molecular blood-brain barrier permeability |
| title_fullStr | Quantitative PET imaging and modeling of molecular blood-brain barrier permeability |
| title_full_unstemmed | Quantitative PET imaging and modeling of molecular blood-brain barrier permeability |
| title_short | Quantitative PET imaging and modeling of molecular blood-brain barrier permeability |
| title_sort | quantitative pet imaging and modeling of molecular blood brain barrier permeability |
| url | https://doi.org/10.1038/s41467-025-58356-7 |
| work_keys_str_mv | AT kevinjchung quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT yassergabdelhafez quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT benjaminaspencer quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT terryjones quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT quyentran quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT lorenzonardo quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT moonschen quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT souviksarkar quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT valentinamedici quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT victorialyo quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT ramseydbadawi quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT simonrcherry quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability AT guobaowang quantitativepetimagingandmodelingofmolecularbloodbrainbarrierpermeability |