Molecular recognition requires dimerization of a VHH antibody

Molecular recognition requires dimerization of a VHH antibody

Camelid heavy-chain-only antibodies are a unique class of antibody that possesses only a single variable domain (termed VHH) for antigen recognition. Despite their apparent canonical mechanism of target recognition, where a single VHH domain binds a single target, an anti-caffeine VHH has been obser...

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Bibliographic Details
Main Authors: Christopher A. Smith, Gregory J. Sonneson, Robert J. Hoey, Jennifer M. Hinerman, Kimberly Sheehy, Richard Walter, Andrew B. Herr, James R. Horn
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Camelid antibody
chemically induced dimerization (CID) systems
crystal structure
dimerization
hapten recognition
ITC
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2215363
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https://www.tandfonline.com/doi/10.1080/19420862.2023.2215363

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