From standardized to individualized margins for online adaptive tumor dose escalation in rectal cancer

From standardized to individualized margins for online adaptive tumor dose escalation in rectal cancer

Abstract Purpose To determine the impact of tumor characteristics such as tumor volume, circumference and location in the rectum on intrafraction motion during dose-escalated MRI-guided radiotherapy of rectal cancer and to explore the potential of PTV margin individualization. Methods Seventy-seven...

Full description

Saved in:

Bibliographic Details
Main Authors:	C. M. Kensen, Lisa Wiersema, Anja Betgen, Doenja M.J. Lambregts, Corrie A.M. Marijnen, Uulke A. van der Heide, Tomas M. Janssen
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	Radiation Oncology
Subjects:	Rectal cancer Online adaptive radiotherapy MRI-guided radiotherapy Intrafraction motion PTV margin Individualized margins
Online Access:	https://doi.org/10.1186/s13014-025-02706-8
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

From CBCT to MR-Linac in Image-Guided Prostate Cancer Radiotherapy Towards Treatment Personalization
by: Florentina Larisa Coc, et al.
Published: (2025-05-01)

A systematic review of prostate bed motion and anisotropic margins in post-prostatectomy external beam radiotherapy
by: T. Hodgins, et al.
Published: (2024-12-01)

Intrafraction motion and impact of margin reduction for MR‐Linac online adaptive radiotherapy for pancreatic cancer treatments
by: Ashleigh Fasala, et al.
Published: (2025-03-01)

Comparative Analysis of Postoperative Radiotherapy Dose Escalation in Oral Cavity Cancer Patients with Positive Margins: A Propensity Score-Matched Study
by: Rashmi Sarawagi, et al.

Analysis of the setup deviations generated in the 6D ExacTrac X-ray system for patients in hypofractionated intracranial radiosurgery treatments
by: Maíra Milanelo Vasques, et al.
Published: (2019-01-01)

Circumferential resection margin as a prognostic factor after rectal cancer surgery: A large population‐based retrospective study
by: Qi Liu, et al.
Published: (2018-08-01)

Intraoperative radiotherapy with a photonic radiosurgical system in the treatment of locally advanced rectal cancer
by: S. N. Potemin, et al.
Published: (2022-03-01)

Outcome of patients with liposarcoma: A retrospective review over 12 Years in a single center
by: Teck Liang Tie, et al.
Published: (2024-06-01)

Reconstructed dose and geometric coverage for tight margins using intrafraction re-planning on an integrated magnetic resonance imaging and linear accelerator system for prostate cancer patients
by: Ingeborg van den Berg, et al.
Published: (2025-04-01)

Deviation of the upper, middle and lower thirds of the rectum during irradiation of rectum cancer
by: Salmic Klemen, et al.
Published: (2025-06-01)

Risk factors for rectal bleeding in prostate cancer after radiotherapy with a validation of current rectal dose constraints
by: Ellen Lund Schaldemose, et al.
Published: (2025-05-01)

Modern principles of neoadjuvant therapy for rectal cancer
by: A. M. Karachun, et al.
Published: (2025-05-01)

Patient-Specific Hyperparameter Optimization of a Deep Learning-Based Tumor Autocontouring Algorithm on 2D Liver, Prostate, and Lung Cine MR Images: A Pilot Study
by: Gawon Han, et al.
Published: (2025-04-01)

Quantifying Intra- and Inter-Observer Variabilities in Manual Contours for Radiotherapy: Evaluation of an MR Tumor Autocontouring Algorithm for Liver, Prostate, and Lung Cancer Patients
by: Gawon Han, et al.
Published: (2025-05-01)

CT-based auto-segmentation of multiple target volumes for all-in-one radiotherapy in rectal cancer patients
by: Xuemin Li, et al.
Published: (2025-08-01)

he Phenomenon of Marginality in the Middle Ages
by: Oleksandr Yakovlev, et al.
Published: (2022-11-01)

Marginal Fit and Fracture Resistance of Vertical Versus Horizontal Margins in Monolithic Zirconia Crowns
by: Mohamed A. Salama, et al.
Published: (2025-02-01)

Enhanced precision in prostate surgery: determining key factors for rectal positive surgical margins through integrated imaging and clinical data analysis
by: Yufan Wu, et al.
Published: (2025-04-01)

Development and validation of a histological calculator for anastomotic margins to predict anastomotic failure among rectal cancer patients treated with neoadjuvant chemoradiotherapy
by: Zhun Liu, et al.
Published: (2025-07-01)

Penile and multiple cutaneous metastases over the pubic region from a rectal adenocarcinoma: An uncommon case
by: Vipul D Yagnik
Published: (2018-01-01)

Staging of Rectal Cancer: MRI Protocol, Pelvic Anatomy, and Definitions
by: Dollphy Garg, et al.
Published: (2025-05-01)

Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis
by: Wenshu Wang, et al.
Published: (2025-05-01)

Radiotherapy for Rectal Cancer and Radiation-Induced Malignancies from Epidemiological and Dosimetric Data
by: Stefanos Kachris, et al.
Published: (2024-12-01)

Impact of Treatment Technique on Testicular Dose and Sexual Activity in Rectal Cancer Patients
by: Poornachandra Tejaswi-Siddappa, et al.
Published: (2024-01-01)

Evaluation of Prognostic Factors in Myxoid Liposarcoma Treated with Combined Neoadjuvant Radiotherapy and Surgical Excision: Systematic Review
by: Giuseppe Francesco Papalia, et al.
Published: (2025-06-01)

Short-term and long-term oncological outcomes of chemoradiotherapy for rectal cancer patients with or without oxaliplatin: a propensity score-matched retrospective analysis
by: Amirali Azimi, et al.
Published: (2024-12-01)

Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review
by: Samatha M Jain, et al.
Published: (2024-12-01)

A rectal ulcer caused by hydrogel spacer insertion: A case report and review of the literature
by: Sen Yagi, et al.
Published: (2025-04-01)

Optimal Sequence for Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer: An Evidence‐Based Review
by: Reza Ghalehtaki, et al.
Published: (2024-10-01)

An introductory study of perceptual marginality in Slovakia
by: Mikuš Roman, et al.
Published: (2016-12-01)

Normal tissue complication probability modeling for late rectal bleeding after conventional or hypofractionated radiotherapy for prostate cancer
by: Christian A.M. Jongen, et al.
Published: (2025-01-01)

The Effect of Injected and Oral Computed Tomography Contrast Agent on Helical Tomotherapy Dose Calculating in Rectal Cancer
by: Fatemeh Tabatabayi, et al.
Published: (2025-03-01)

Dose Escalation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Short-Term Efficacy and Toxicity of VMAT–SIB vs. 3D-CRT
by: Suzana Stojanovic-Rundic, et al.
Published: (2025-03-01)

[Comment] Robotic surgery is associated with a decreased risk of circumferential resection margin positivity compared with conventional laparoscopic surgery in patients with rectal cancer undergoing mesorectal excision: a systematic review and meta-analysis
by: Huang Shenghui, et al.
Published: (2024-10-01)

How Do Passive Margins Convert to Active Margins?
by: Timothy M. Kusky, et al.
Published: (2025-05-01)

Adjuvant radiotherapy for pleomorphic dermal sarcoma
by: D. Helbig, et al.
Published: (2024-12-01)

Bevacizumab is associated with delayed anastomotic leak after low anterior resection with preoperative radiotherapy for rectal cancer: a case report
by: Erika Machida, et al.
Published: (2019-01-01)

Rectal spacer use and overall long-term healthcare costs: payer perspective
by: James B. Yu, et al.
Published: (2025-08-01)

Organ preservation in rectal cancer with contact x-ray brachytherapy (Papillon): a refined Swiss protocol to improve real-world feasibility
by: Cristina Picardi, et al.
Published: (2025-07-01)

Deep margin elevation: a systematic review
by: Z. S. Khabadze, et al.
Published: (2021-10-01)