From standardized to individualized margins for online adaptive tumor dose escalation in rectal cancer

From standardized to individualized margins for online adaptive tumor dose escalation in rectal cancer

Abstract Purpose To determine the impact of tumor characteristics such as tumor volume, circumference and location in the rectum on intrafraction motion during dose-escalated MRI-guided radiotherapy of rectal cancer and to explore the potential of PTV margin individualization. Methods Seventy-seven...

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Bibliographic Details
Main Authors: C. M. Kensen, Lisa Wiersema, Anja Betgen, Doenja M.J. Lambregts, Corrie A.M. Marijnen, Uulke A. van der Heide, Tomas M. Janssen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Radiation Oncology
Subjects:
Rectal cancer
Online adaptive radiotherapy
MRI-guided radiotherapy
Intrafraction motion
PTV margin
Individualized margins
Online Access:https://doi.org/10.1186/s13014-025-02706-8
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https://doi.org/10.1186/s13014-025-02706-8

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